L'équipe du département de pharmacologie






Université Bordeaux 2 CHU de Bordeaux INSERM
Département Hospitalo-Universitaire de Pharmacologie de Bordeaux

Pharmacoepidemiology Unit activities

From the conception to the valorisation...

Fields of research for the evalutation of medicines in a real-life setting are multiple:



Development of a signal detection system for adverse drug reaction by using healthcare databases.

  • European Project FP7 ALERT


Measurement of the exposition in pharmacoepidemiology: comparison of the data from the bases of reimbursement of the French Healthcare Insurance and from the bases of declarative data.


Interest and limits of healthcare information from the databases of reimbursement.


  • CESIR-U study



Study of the association between the drug consumption and road or work related accidents.

  • CESIR-U study



Study of the consumption of medicines by elderly subjects (poly-medication, inappropriate medication, adherence, etc.) - Study of the association between the consumption of medicines, cognitive decline and mortality.

  • PAQUID & 3C cohorts


Study of the medicines consumption and impact in Alzheimer's disease.

  • Mageurt study



Study of antibiotic therapeutical strategies in chronic obstructive pulmonary disease (COPD).


Observational study of therapeutical strategies in acute sinusitis.


Study of the consumption of medicines in asthmatic subjects (modalities of use, adherence, side effects).

  • CORINES study



Medico-economic evaluation of spa treatments.

  • Escape study


Investigation of the consumption of medicines and the risks associated with NSAIDS.


Pragmatic medico-economic evaluation of a NSAIDS interest in gonarthosis treatment.

  • EMES study


Assessment of healthcare resource utilization by patients with low back pain in general practice.

  • Low back pain study



Investigation of therapeutical strategies for post myocardial infarct care.



Longitudinal study of an anti-epileptic medicine.





Study of the consumption of benzodiazepines and neuroleptics in the general population.

Patterns and correlates of benzodiazepine use in the French general population. Eur J Clin Pharmacol. 2004 Sep;60(7):523-9. Lagnaoui R, Depont F, Fourrier A, Abouelfath A, Bégaud B, Verdoux H, Moore N.


Study of the consumption of benzodiazepines and neuroleptics in the elderly subject.

Benzodiazepine use in the elderly: the EVA Study. Rev Epidemiol Sante Publique. 2003 Jun;51(3):317-26. French. Lechevallier N, Fourrier A, Berr C.

Benzodiazepine use and risk of dementia: a nested case-control study. J Clin Epidemiol. 2002 Mar;55(3):314-8. Lagnaoui R, Bégaud B, Moore N, Chaslerie A, Fourrier A, Letenneur L, Dartigues JF, Moride Y.

Benzodiazepine use and wine consumption in the French elderly. Br J Clin Pharmacol. 2001 Oct;52(4):455-6. Lagnaoui R, Moore N, Dartigues JF, Fourrier A, Bégaud B.

Benzodiazepine use in an elderly community-dwelling population. Characteristics of users and factors associated with subsequent use. Eur J Clin Pharmacol. 2001 Aug;57(5):419-25. Fourrier A, Letenneur L, Dartigues JF, Moore N, Bégaud B.

Benzodiazepines and hip fractures in elderly people: case-control study. BMJ. 2001 Mar 24;322(7288):704-8. Pierfitte C, Macouillard G, Thicoïpe M, Chaslerie A, Pehourcq F, Aïssou M, Martinez B, Lagnaoui R, Fourrier A, Bégaud B, Dangoumau J, Moore N.


Perception and attitudes of prescribers regarding antidepressants.

Patterns of neuroleptic drug prescription: a national cross-sectional survey of a random sample of French psychiatrists. Br J Clin Pharmacol. 2000 Jan;49(1):80-6. Fourrier A, Gasquet I, Allicar MP, Bouhassira M, Lépine JP, Bégaud B.



Investigation of the medico-economic interest of spa therapy for the treatment of different pathologies.

  • Escape study (osteoarthritis)
  • PriSMe study (metabolic syndrome)



Study of chemotherapies and targeted therapies in the treatment of different cancers.



Study of the consumption of gastro-protective agents in users of NSAIDs.


Study of the role of NSAIDs in the occurrence of livid hepatitis.

  • SALT study